The 49ers are 5-0. They and the Kansas City Chiefs are the only undefeated teams in the NFL. The 49ers face a Washington Commanders team that's 1-3-1 and coming off an embarrassing time-management debacle that cost them a chance to beat the New York Giants in overtime.

Commanders vs. 49ers Polymarket prediction prices for Monday Night Football on October 19, including winner probabilities, spread and total.

The Washington Commanders and San Francisco 49ers close out Week 6 of the 2026 NFL season on Monday Night Football in what may end up being a lopsided game. The

The 49ers and Brock Purdy look to keep rolling against the Washington Commanders on "Monday Night Football." USA TODAY Sports is providing live updates:

After the San Francisco 49ers brought back Deebo Samuel and Dre Greenlaw, Kyle Juszczyk wants another reunion in San Francisco.

The Commanders face a critical test against the 49ers, with a loss putting Washington in the middle of an unwanted NFL first.

The Washington Commanders and San Francisco 49ers meet for Monday Night Football in Santa Clara, California. Here are the best prop bets for the 8:15 p.m. ET matchup.

Novig prices San Francisco at 79% to defeat Washington, compared with 22% for the Commanders. Tampa Bay checks in at 59% against Cleveland, while the Guardians sit at 42%. SportsLine forecasts a 32-23 49ers victory and gives the Rays a narrow advantage in Monday's baseball matchup. For full details, check out our Novig promo code review.

Monday Night Football schedule, TV channel, time, streaming, how to watch San Francisco 49ers vs Washington Commanders NFL Week 6 game on Oct. 19.