KLF5 appears to fuel pancreatic cancer metastasis by reprogramming epigenetic controls, offering a potential new therapeutic target.

Memorial Sloan Kettering Cancer Center investigators report that T cell interferon-γ (IFNγ) orchestrates a dendritic-cell–natural-killer-cell circuit that suppresses leptomeningeal metastases in mouse ...

The scientists found that KLF5 had the greatest effect specifically promoting the growth and invasion of metastatic cells, ...

Many patients with metastatic cancers receive therapy that is initially highly effective, often resulting in complete remission. However, cancer cells have a remarkable capacity to evolve resistance ...

Veronica Paulus is a former STAT intern supported by the Harvard University Institute of Politics. After patients go into remission, there may still be undetected cancer cells lying dormant through ...

To survive in ever-changing conditions in the body, cancer cells often need to alter their metabolism. 1 This ability to adapt is especially critical for their spread to other parts of the body. “This ...

Scientists have discovered why ovarian cancer spreads so rapidly through the abdomen. Cancer cells enlist normally protective abdominal cells, forming mixed groups that work together to invade new ...

Breast cancers frequently spread to the bone, establishing tumors that are largely impervious to treatment and are associated with poor patient prognoses. A deficiency in the oxygen-carrying capacity ...

Scientists are looking for answers about how these confounding trips, known as metastases, occur throughout the human body Illustration of a human cancer cell Amber Dance, Knowable Magazine Back in ...

A protein found in our cells could act as an early warning sign for aggressive cancers—and a new target for drugs to stop them spreading. This is the discovery of scientists from Brunel University of ...