Here we report that ALDH1L1 (FDH, a folate enzyme with tumor suppressor-like properties) inhibits cell motility. The underlying mechanism involves F-actin stabilization, re-distribution of cytoplasmic ...

Accumulation of pathologic tau protein plays a pivotal role in the neurodegeneration of Alzheimer's disease (AD) and many other tauopathies. Thus, amelioration of pathological tau aggregates in the ...

Recent research has observed that chemical modifications called phosphorylation of various proteins *1) in brain neurons dynamically regulates in controlling sleep and wakefulness. On the other hand, ...

Mouse models and biochemical studies have implicated protein phosphatase 2A (PP2A) in curbing tau hyperphosphorylation in Alzheimer’s and other diseases, but brain slices and Western blots can only ...

Recent research has observed that chemical modifications called phosphorylation of proteins in brain neurons dynamically regulate sleep and wakefulness. But the protein kinases that suppress sleep and ...

Fas (CD95), a transmembrane protein belonging to tumor necrosis factor receptor family, is a key player in apoptosis induction. Activated Fas recruits the adaptor molecule Fas-associated death domain ...

This study is led by Prof. Jian-Zhi Wang (Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology), Prof. Jie Zheng (Department of Neurobiology, School of ...