Certain epigenetic modifications can directly control how genetic material is packed in the nucleus, RIKEN researchers have ...

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...

Strands of DNA wrapped around a histone. Credit: Molekuul/Science Source Histones are among the most abundant proteins in the body. They act as spools that help compact DNA so our enormous genomes ...

Researchers identify a novel centromere-specific histone H3 variant called the “CENP-A”, which reconstituted with H4 forms “CENP-A–H4” octasome and explore its role in mitosis. Centromeres, ...

Researchers identify hundreds of candidate histone proteins in bacteria, including one with an unusual way of binding to DNA. Now, Warnecke and colleagues are challenging the idea that these ...

A research team led by Dr. Xiang David Li, Associate Professor from the Department of Chemistry, in collaboration with Dr. Karen Wing Yee Yuen from the School of Biological Sciences and Dr. Jason Wing ...

The biology of histone proteins encompasses their synthesis in the cytosol, nuclear import and incorporation into nucleosomes, as well as subsequent eviction from chromatin, redeposition, storage or ...

If all the DNA in a human cell was stretched out end to end, it would be roughly six feet long. That’s a lot of genetic information to pack into a cell that is, on average, one-fifth the size of a ...

In a recent study published in the journal Science Advances, a group of researchers investigated the role of histone modifications in human aging by developing and evaluating histone-specific age ...