Microtubules are dynamic, tubular polymers composed of αβ-tubulin dimers that form an essential framework within eukaryotic cells. They orchestrate a wide range of cellular functions including ...

Patients with Parkinson's disease suffer a specific loss of dopaminergic neurons from the midbrain region that controls motor function. The exact mechanism of this selective neurodegeneration is ...

Microtubules -- cellular "highways" that deliver cargo to the cell membrane for secretion -- have a surprising role in pancreatic beta cells. Instead of facilitating glucose-stimulated insulin ...

Microtubules are cell constituents that display several astounding properties and a unique pattern of behavior during the cell cycle. Microtubules are regulated by several proteins and complexes, and ...

Certain chemotherapy drugs, including paclitaxel (Taxol), block cancer cell division by targeting microtubules—structural polymers that are critical for cell division and other functions. Such ...

Microtubules function in concert with associated proteins that modify microtubule behavior and/or transmit signals that effect changes in growth. To better understand how microtubules and their ...

This is a preview. Log in through your library . Abstract γ-Tubulin is a conserved component of microtubule-organizing centers and is thought to be involved in microtubule nucleation. A recently ...

Zachary Gergely, Ammon Crapo, Loren Hough, J. Richard McIntosh, and Meredith D. Betterton (2016). Molecular Biology of the Cell27, 3490. arXiv DOI: 1604.08134. DOI ...

The protein NEK7 regulates neuron formation, as it is required for dendrite growth and branching, as well as the formation and shaping of dendritic spines. The protein NEK7 regulates neuron formation, ...

Identifying a mechanistic link between the loss of CFTR function and altered cell-signaling control in CF airway epithelial cells – We have identified a number of cell regulatory changes in CF that ...

The protein NEK7 regulates neuron formation, as it is required for dendrite growth and branching, as well as the formation and shaping of dendritic spines. These are the main conclusions of a study ...