Translational proof-of-concept studies for gene therapeutics often match the payload gene sequence to the preclinical animal model as this avoids immune responses that could compromise drug efficacy.

Accumulating evidence has revealed noncoding RNAs (ncRNAs) as versatile regulators in skeletal muscle development, extending beyond their canonical roles as nontranslating transcripts. Recent ...

Skeletal muscle is the type of muscle that controls movement. Problems with these muscles can be minor, life-threatening, or ongoing problems that make it hard to perform basic daily activities.

Spinal muscular atrophy and muscular dystrophy both affect muscle size and function, causing weakness and leading to health complications like difficulty walking, swallowing, and, for some people, ...

Fat, not skeletal muscle, accounted for most of the weight loss. According to the study, GLP-1 medicines reduced body fat in obese mice much more than lean body mass, and fat and liver mass fell ...

Among adults with vs. without obstructive sleep apnea, skeletal muscle density/quality was reduced and skeletal muscle ...