SBS mutational signatures are based on the segmentation of the mutations in 96 mutation types defined by the substitution type, the base before the substitution, and the base after the substitution.
Analysis of Micro-seq data from 384 samples (56 patients, 40–92 years old) each containing around 200 laser-capture micro-dissected crypts (N = 76,800 crypts in total) identified 289 single nucleotide ...
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