Deoxyribonucleic acid (DNA) is able to form non-canonical four-stranded helical structures with diverse folding patterns known as G-quadruplexes (G4s). G4 topologies are classified based on their ...

DNA G-quadruplexes (G4s), formed by guanine-rich sequences in mammalian genomes, are non-canonical structures implicated in gene regulation. However, their strand-specific genomic distribution and ...

DNA, the genetic material compacted in chromosomes, stores information to regulate all the cell processes in the body. Two decades ago, in addition to the widely known Watson-Crick double helix model ...

A collaboration led by Distinguished Professor Dr. Kazunori Ikebukuro from Tokyo University of Agriculture and Technology (TUAT), Japan, discovered that G-quadruplex (G4)-forming DNA binds myoglobin ...

A new research paper was published in Oncotarget entitled, "G-quadruplex landscape and its regulation revealed by a new antibody capture method." In this new study, researchers Subhamoy Datta, Manthan ...

Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such structure, the G-quadruplex (G4), looks like a knot. These knots can play ...

Guanine quadruplexes (G-quadruplexes or G4s) are unusual nucleic acid structures with distinct biological and chemical functions. They have occupied significant attention in the nucleic acid world ...

A special form of four-stranded DNA, recently seen in human cells, has been found to interact with a gene that causes Cockayne Syndrome when faulty. A special form of four-stranded DNA, recently seen ...

Cockayne syndrome (CS) is a rare disease that causes short stature, premature aging (progeria), severe photosensitivity, and moderate to severe learning delay. A new study by researchers from the ...