ascopubs.org

Serum Human Epidermal Growth Factor 2 Extracellular Domain as a Predictive Biomarker for Lapatinib Treatment Efficacy in Patients With Advanced Breast Cancer

Annual Hazard Rates of Recurrence for Breast Cancer During 24 Years of Follow-Up: Results From the International Breast Cancer Study Group Trials I to V We analyzed sHER2 and tissue HER2 (tHER2) data ...
ascopubs.org

Role of serum HER2 (sHER2) levels to predict acquisition of HER2 overexpression in patients with metastatic lesions of breast cancer with HER2-negative/unknown at the primary site.

Early detection of tumor recurrence in patients with asymptomatic breast cancer with tumor marker kinetics and whole body imaging. This is an ASCO Meeting Abstract from the 2011 ASCO Annual Meeting I.
Nature

Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

ErbB receptors comprise an extracellular region of about 630 amino acids that contains four domains (I/L1, II/CR1, III/L2 and IV/CR2) arranged as a tandem repeat of a two-domain unit, a single ...
Nature

Predictive value of HER2 serum levels in patients treated with lapatinib or trastuzumab – a translational project in the neoadjuvant GeparQuinto trial

We were able to demonstrate a predictive value of serum HER2 (sHER2) in patients receiving trastuzumab in the neoadjuvant GeparQuattro trial. However, the role of sHER2 in patients receiving ...