Every gene tells a story, but the way that story is edited can determine whether a patient lives or dies. In one of the most ...

Spatial transcriptomics has advanced the study of gene expression in tissues, but most current approaches rely on 3′-end sequencing and provide limited information on alternative splicing (AS).

Anembryonic pregnancy, a form of early miscarriage in which a gestational sac develops but an embryo never forms, accounts ...

In an article published in the journal RNA, Karan Bedi, a bioinformatician in Mats Ljungman's lab, Department of Radiation Oncology at the University of Michigan Medical School, investigated the ...

The cryo-EM structure of the splicing intermediate known as the C* complex from human. An HDR-independent therapeutic genome-editing approach corrected the splice-site mutation in Lama2 in a mouse ...

The nucleus of each of your cells contains all the genetic information (the genome) necessary to build every type of cell and protein in your entire body. Like a complex library in a tiny space 50 ...

A wide spectrum of cancer-associated genetic alterations, including those that result in changes to the splicing of pre–messenger RNA (mRNA), can lead to the presentation of aberrant peptides as ...

Immunotherapies that target the CD20 antigen have revolutionized how patients with a variety of blood cancers and hematologic disorders have been treated. However, many patients develop resistance to ...

Researchers developed molecules, called splice-switching oligonucleotides (SSOs) that bind to the RNA molecules encoding a protein known as REST. In neuroendocrine tumors, these RNAs are incorrectly ...

A study conducted by the University of Liège and Rockefeller University reveals, with near-atomic precision, the three-dimensional structure and function of a gigantic molecular machine essential to ...