More than 100 million people in the U.S. will be in the path of an intense March storm starting Friday as the sprawling multi-day system threatens fires, blizzards, tornadoes, and flooding as it tracks eastward across the Great Plains.

A huge storm system crossing the U.S. threatens to unleash tornadoes Friday in the Mississippi Valley, blizzards in the northern Plains and dry, gusty conditions in Texas and Oklahoma that pose an extreme risk of wildfires.

Another unusually intense March storm is coming this week, and it may cause a bit of déjà vu, with severe thunderstorms, heavy rain, powerful wind gusts, wildfire risks and blizzard conditions possible across the country.