Turning his attention to the secondary endpoint changes—mean systolic blood pressure and hematocrit levels—Antman suggested that empagliflozin favorably affects cardiac preload and afterload, which ...

Orchestra Biomed researchers found AVIM therapy acutely lowered systolic blood pressure and improved left ventricular volumes ...

It decreases preload through venodilation and at higher doses also can cause decreased afterload with resulting improved cardiac output. Nitroglycerine's side effects include headache and hypotension.

Proposed mechanisms include reductions in plasma volume, cardiac preload and afterload, alterations in cardiac metabolism, reduced arterial stiffness, and interaction with the Na + /H + exchanger." ...

These associations were independent of left ventricular mass index and cardiac preload and afterload measures.