Proteins are the workhorses of the cell, but many only function as part of larger multi-protein machines. These complexes perform essential tasks, such as muscle contraction, energy production, and ...

ABSTRACT: Abnormal cell division leading to chromosomal instability is a hallmark of cancer development. Accurate chromosome classification Lysis plays an important role in cell division, and the ...

Centromere function requires the proper coordination of several subfunctions, such as kinetochore assembly, sister chromatid cohesion, binding of kinetochore microtubules, orientation of sister ...

An enigmatic L-shaped structure found underground near the pyramids at Giza may be an entrance to a mysterious deeper feature below it. When you purchase through links on our site, we may earn an ...

Our editorial process produces two outputs: (i) public reviews designed to be posted alongside the preprint for the benefit of readers; (ii) feedback on the manuscript for the authors, including ...

Crowning a quest into a very well-guarded secret: Structure of the kinetochore corona finally revealed Date: April 8, 2022 Source: Max Planck Institute of Molecular Physiology Summary: During cell ...

In human cells, lengthy strands of DNA have to be carefully organized and compacted so they'll fit into the nucleus; our genome is arranged into chromosomes that have to be duplicated each time a cell ...

The kinetochore is a dynamic proteinaceous structure that forms on centromeric chromatin, which is in turn epigenetically labelled with histone H3 variant, CENP-A. The kinetochore connects the spindle ...

Kinetochores perform an essential role in eukaryotes, coupling chromosomes to the mitotic spindle. In model organisms they are composed of a centromere-proximal inner kinetochore and an outer ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Partitioning of the genome in meiosis occurs ...