SportsLine's proven model has simulated New York vs. San Diego 10,000 times and released its MLB best bets for Clay Holmes vs. Yu Darvish on Wednesday

The New York Mets (62-46) and the San Diego Padres (59-49) wrap up a 3-game series Wednesday at Petco Park in San Diego. First pitch is scheduled for 4:10 p.m. ET (MLB Network). Let's analyze BetMGM Sportsbook's MLB odds around the Mets vs. Padres odds and make our expert MLB picks and predictions for the best bets.

The Padres have been one of the better teams in baseball at avoiding strikeouts against lefties, punching out just 19.2 percent of the time, so I’m targeting another way to bet on Manaea to pitch well Tuesday.