Plants produce a wide diversity of compounds. Broadly, these are separated into primary metabolites, which are necessary for ...

Aggressive prostate cancer (PCa) variants associated with androgen receptor signaling inhibitor (ARSI) resistance and metastasis remain poorly understood. Here, we identify the axon guidance ...

imageimagePatients with inflammatory arthritis face increased heart and lung complications, which current treatments fail to address. This study identifies a novel therapeutic approach by selective ...

N6-methyladenosine (m 6 A) exerts many of its regulatory effects on eukaryotic mRNAs by recruiting cytoplasmic YT521-B homology-domain family (YTHDF) proteins. Here, we show that in Arabidopsis ...

Spatial metabolomics is transforming our understanding of microbial systems by uncovering the localized molecular dynamics ...

imageimageThis study presents and characterizes a Dnmt3a mutant mouse model which carries a heterozygous hotspot R878H mutation frequently found in human cancers, providing insights into Dnmt3a-mutant ...

Neoantigen vaccine is a promising breakthrough in tumor immunotherapy. However, the application of this highly personalized strategy in the treatment of solid tumors is hindered by several obstacles, ...

The ER membrane protein SELENOT has been previously suggested to be neuroprotective, but its contribution to neuronal pathophysiology has not been thoroughly investigated. This study reports that ...

Immune memory plays a critical role in the development of durable antimicrobial immune responses. How precisely mRNA vaccines train innate immune cells to shape protective host defense mechanisms ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Patients suffering from progranulin (PGRN) ...

Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease ...

imageimageJunctions between the endoplasmic reticulum (ER) and the nuclear envelope (NE) form a narrow and constricted hourglass shape, suggesting that these junctions are formed and maintained by ...