6.8K views · 29 reactions | PKU is a rare genetic condition where the body can’t process phenylalanine, an amino acid found in many foods. With a low-protein diet and proper care, people with PKU can lead healthy lives. #NWGH #PKUAwareness #HealthMatters | Northwest General Hospital & Research Centre | Facebook
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The first reaction in the catabolism of phenylalanine uses the enzyme phenylalanine hydroxylase (PAH) to convert phenylalanine into tyrosine, a different amino acid. PKU results from defects in this enzyme. It has been hypothesized that phenylalanine is both the substrate and an allosteric regulatory molecule for PAH. If this is true, draw two models to show how PAH would appear if the phenylalanine concentration is low (inactive enzyme) vs. high (active enzyme). Label phenylalanine, the alloste
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