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1:00
YouTube
MedLecturesMadeEasy
Conditions that alter concentration of thyroxine-binding globulin
Increased TBG: Estrogens (eg, pregnancy, oral contraceptives, HRT) & estrogenic medications (eg, tamoxifen) Acute hepatitis Decreased TBG: Androgenic hormones High-dose glucocorticoids / hypercortisolism Hypoproteinemia (eg, nephrotic syndrome, starvation) Chronic liver disease
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