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mind.org.uk
It’s important to be clear: Premenstrual Dysphoric Disorder (PMDD) is not just “severe PMS.” PMDD is a neuroendocrine condition. It’s not caused by a simple hormone imbalance, but by the brain’s heightened sensitivity to the normal hormonal changes that occur in the luteal phase of the menstrual cycle. One key player is allopregnanolone, a neurosteroid made from progesterone. In most women, it calms the brain by activating GABA-A receptors. But in women with PMDD, this pathway works differently.
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